From among the thousands of research grants made by the U.S. National Institutes of Health, our colleagues at NIH Sales have helped BioTechniques select some of the largest that place particular emphasis on developing clinical and research imaging and image analysis.
Morphometry Biomedical Informatics Research Network(mBIRN, 5U24RR021382-04)
Bruce R. Rosen
Massachusetts General Hospital, Boston, MA
$5,123,449.00
The project is developing the ability to conduct clinical imaging studies across multiple sites, to analyze imaging data with the most powerful software regardless of development site, and to test new hypotheses on large collections of subjects with well-characterized image and clinical data would have a demonstrable positive impact on this field. The mBIRN (established in 2001) has made substantial progress in uniting seven sites doing neuroanatomic analysis and will continue to optimize data acquisition, incorporate new technologies, and extend database capabilities.
Center for High-Throughput Minimally-Invasive Dosimetry(5U19Al067773-03)
David Jonathan Brenner
Columbia University Health Sciences, New York, NY
$4,738,948.00
The project develops technologies and products for the sort of very high-throughput, minimally-invasive radiation biodosimetry that would be required after a large-scale radiological event. Current “high-throughput” biodosimetry can, at best, assess a few hundred individuals per day. The project will develop devices capable of assessing tens of thousands of individuals per day, with three primary foci: cytogenetics, functional genomics, and metabolomics. The project includes an automated biodosimetry based on robotics and advanced high speed, automated image acquisition, based on several endpoints (micronuclei and y-H2AX foci) and several tissues (blood lymphocytes, reticuloctyes, and exfoliated cells from urine).
Center for In Toto Genomic Analysis of Vertebrate Development(5P50HG004071-02)
Marianne Bronner-Fraser
California Institute of Technology, Pasadena, CA
$3,529,861.00
The project assembles a multidisciplinary group to develop technologies for imaging and mutating every developmentally important vertebrate gene. Novel “in toto imaging” tools can digitize in vivo data—systematically, rapidly, quantitatively, and in large volumes. Combining in toto imaging with novel gene traps permits a rapid screening for developmentally relevant expression patterns, combined with the ability to immediately mutagenize genes of interest. Ultimately, the project will develop real-time in toto image analysis of reporter gene expression and design of quantitative, multiplexed hybridization chain reaction (HCR) amplifiers for in vivo imaging with active background suppression.
Data provided by NIH Sales, Inc., 2 Snowmound Ct., Rockville, MD 20850, USA.
Phone 301-279-7175. Web address: www.nihsales.net
