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ELISA For The Measurement of High Molecular Weight Adiponectin
Samuel Pearlman, Jennifer Lawson and Judy Johnson
Department of Immunoassay Development | R&D Systems, Inc., 614 McKinley Pl. NE, Minneapolis, MN, 55413
Sponsored by R&D Systems
Adiponectin is an adipocyte-derived protein with diverse biological functions. It circulates in plasma as low molecular weight (LMW) trimers, medium molecular weight (MMW) hexamers, and high molecular weight (HMW) multimers. The different oligomeric forms have been suggested to exert distinct actions on specific target tissues. The HMW Adiponectin is the primary bioactive form with insulin-sensitizing activity and its circulating levels negatively correlate with obesity, insulin resistance and coronary artery disease (CAD). Current ELISA assays to detect HMW Adiponectin require the laborious process of selective enzyme digestion of the LMW and MMW forms. We have developed a novel ELISA that utilizes HMW Adiponectin-specific antibodies. This easy-to-use assay does not require any pretreatment of the sample and provides excellent reproducibility.
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