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POSTER
Development and Characterization of Human iPSC-derived Neurons for Drug Discovery Applications
Lucas Chase1, Monica Strathman1, Jeff Grinager1, David Majewski1, Regina Whitemarsh2, Sabine Pellett2, Oksana Sirenko3, Jayne Hesley3, Penny Tavormina3, Casey Stankewicz1, Matt George1, Ning Liu1, Nathan Meyer1, Matthew Riley1, Xuezhu Feng1, Eric Johnson2, Wen Bo Wang1 and Brad Swanson1
1Cellular Dynamics International, Inc., Madison, WI 53711; 2Department of Bacteriology, University of Wisconsin, Madison, WI 53706; 3Molecular Devices, Sunnyvale, CA 94089
Sponsored by Cellular Dynamics CDI
1Cellular Dynamics International, Inc., Madison, WI 53711; 2Department of Bacteriology, University of Wisconsin, Madison, WI 53706; 3Molecular Devices, Sunnyvale, CA 94089
Sponsored by Cellular Dynamics CDI
The human brain is a complex organ that has consistently been proven difficult to model in vitro. With current models suffering from various issues, including biological relevance, functionality, and reproducibility, a significant focus within the drug discovery field has been on the development and validation of more relevant in vitro human model systems. Human neurons derived from induced pluripotent stem cells (iPSCs) provide an ideal platform for disease modeling. The data demonstrate the robustness of iCell® Neurons to recapitulate in vivo neuronal functions. In addition, these cells are amenable to various assay systems, including high content image-based assays, standard cell-based assays and toxigenicity testing, thus enabling powerful new strategies for basic biological and drug discovery applications.
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