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Multiplexed High Content Assays for Predictive Hepatotoxicity using Induced Pluripotent Stem Cell Derived Hepatocytes
Oksana Sirenko, Shannon Einhorn1, Jayne Hesley, Grischa Chandy, Vanessa Ott1, and Evan F Cromwell
Molecular Devices, LLC, 1311 Orleans Drive, Sunnyvale, CA 94089
1Cellular Dynamics International, 525 Science Drive, Madison WI 53711
Sponsored by Cellular Dynamics CDI
Molecular Devices, LLC, 1311 Orleans Drive, Sunnyvale, CA 94089
1Cellular Dynamics International, 525 Science Drive, Madison WI 53711
Sponsored by Cellular Dynamics CDI
A large percentage of drugs fail in clinical studies,or are withdrawn from the market due to hepatic toxicity. Therefore, highly predictive in vitro assays suitable for safety and efficacy testing are extremely important for improving the drug development process and reducing drug attrition. Accordingly, there is great interest in using stem cells as tools for screening compounds during early drug development. Human hepatocytes derived from stem cells can greatly accelerate the development of new chemical entities and improve drug safety by offering more clinically relevant cell-based models than those presently available. Human induced pluripotent stem cell (iPSC) derived hepatocytes express appropriate hepatocyte markers and demonstrate intrinsic hepatocyte functions similar to primary cells. We demonstrate several models for assessing general and specific hepatotoxicity that are well-suited for automated screening environments.
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