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High-Content and High-Throughput Screening Approaches in 1536 Well Cycloolefin Microplates
Claudia Kaiser1, Felix Neugart2, Angelika Hausser2, Christian Holz3, Cathleen Salomo3, Rainer Heller1
1Greiner Bio-One GmbH, Maybachstrasse 2, D-72636 Frickenhausen, Germany,
2Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, D-70569 Stuttgart,
3Molecular Devices (Germany), Bismarckring 39, D-88400 Biberach an der Riss,
A suitable High-Throughput and High-Content Screening strategy has a major impact on drug discovery. The use of the most advanced technologies is a major prerequisite for successful screening.
Microscopic systems, microplate readers and consumables like microplates undergo continuous optimization to improve sensitivity, accuracy and ease of use.
SCREENSTAR is an advanced 1536 well microplate with a clear cyclooolefin film bottom [190m] which allows sensitive signal detection with fluorescence and transmission measurements.
In HTS fluorescence assays using the SpetraMax® Paradigm®, the latest microplate reader development from Molecular Devices, and in a HCS approach with the ImageXpress as microscopic system the superior properties of SCREENSTAR were proofed.
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