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High Throughput
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A large percentage of new drugs fail in clinical studies due to cardiac toxicity. Therefore development of highly predicative in vitro assays suitable for high throughput screening (HTS) is extremely important for drug development.
Accurate determination of molecular concentrations is a prerequisite to the use of purified biomolecules for a multitude of downstream applications. Quantification is routinely accomplished by spectrophotometric analysis.
Protein Tyrosine Kinases (PTKs) play important roles in modulating a wide variety of cellular events, including differentiation, proliferation, metabolism and apoptosis. Those regulations are mediated by a series of signal cascades that involve phosphorylation of tyrosine residues in target proteins.
Introduction: Array Tape is a continuous, flexible polymer serially embossed with reaction wells in customized volumes and formats. The Array Tape Platform includes modular liquid handling (Nexar), detection (Araya) and thermocycling (Soellex) instruments that increase throughput, flexibility and cost savings compared to microplate-based technologies.
The chemokine receptor CXCR4 has multiple critical functions in normal physiologies including embryonic development of the cardiovascular, hemopoietic and central nervous systems. It has also been implicated in disease pathologies such as HIV infection, cancer metastasis, leukemia progression and rheumatoid arthritis, and is fueling the search for small molecule CXCR4 antagonists as a means for intervention1.
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