The chemokine receptor CXCR4 has multiple critical functions in normal
physiologies including embryonic development of the cardiovascular,
hemopoietic and central nervous systems. It has also been implicated in
disease pathologies such as HIV infection, cancer metastasis, leukemia
progression and rheumatoid arthritis, and is fueling the search for small
molecule CXCR4 antagonists as a means for intervention1.
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