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POSTER
HTRF Ligand Binding Assay for the Chemokine Receptor CXCR4
Wendy Goodrich1, Gary Prescott1, Peter Banks1, François Degorce2, Nicolas Pierre3
1:BioTek Instruments, Inc., Winooski, Vermont, USA • 2:Cisbio Bioassays, Bagnols-sur-Cèze, France • 3:Cisbio US, Bedford, Massachusetts, USA
Sponsored by BioTek Instruments GmbH
Published in December 2010 2011 (p.6) DOI:  10.2144/000113597 Sponsored,vendor-submitted protocol
The chemokine receptor CXCR4 has multiple critical functions in normal physiologies including embryonic development of the cardiovascular, hemopoietic and central nervous systems. It has also been implicated in disease pathologies such as HIV infection, cancer metastasis, leukemia progression and rheumatoid arthritis, and is fueling the search for small molecule CXCR4 antagonists as a means for intervention1. Here we demonstrate the suitability of the Tag-lite HTRF technology for CXCR4 ligand binding assays for high throughput screening applications. Automated assay performance and pharmacology will be presented.
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