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Vision is the most precious of our senses, and its appearance in the animal kingdom was almost certainly a major driving force in the radiation of species that occurred around 550 million years ago....
Shane Marine, Erica M. Stec, Peter Chase, Ira Hoffman, Stacey Szymanski, Adam Simon, Xiao-Ping Shi, Steven Bartz, Ansu Bagchi, Eric Minch, John Majercak, Ken Koblan, Daria Hazuda, Mark Shearman, Adam Gates, Min Xu, Thomas Rosahl, Dirk Beher, William J. Ray, David J. Stone, Amy Espeseth, Marc Ferrer, Berta Strulovici
Multiparametric assays generate biological activity profiles that provide valuable insight into complex disease models. The use of multiple assay measurements in RNA interference (RNAi)...
Shane Marine, Erica M. Stec, Peter Chase, Ira Hoffman, Stacey Szymanski, Adam Simon, Xiao-Ping Shi, Steven Bartz, Ansu Bagchi, Eric Minch, John Majercak, Ken Koblan, Daria Hazuda, Mark Shearman, Adam Gates, Min Xu, Thomas Rosahl, Dirk Beher, William J. Ray, David J. Stone, Amy Espeseth, Marc Ferrer, Berta Strulovici
In some PCR reactions, primers containing portions noncomplementary to the target region (referred to as flaps) are commonly used to add a utility sequence, such as a restriction or universal...
Lynne Lederman
Cells rely on signals to regulate their growth, movement, and metabolism. These signals can be in the form of molecules in the environment: nutrients, compounds secreted by other cells like hormones...
Richard D. Medwid, Lara Krebs, Shellie Welch
Many types of commercially valuable recombinant proteins produced by fermentation are expressed at high levels in Escherichia coli. Often, high-level expression in the host results in the formation...
Lise Lotte Hansen, Bo Eskerod Madsen, Kristina Pedersen, Carsten Wiuf
Single nucleotide polymorphisms (SNPs) are highly abundant in the genome and especially useful in the search for disease susceptibility genes via population-based association or linkage studies....
Luis G. Acevedo, A. Leonardo Iniguez, Heather L. Holster, Xinmin Zhang, Roland Green, Peggy J. Farnham
The technique of chromatin immunoprecipitation (ChIP) is a powerful method for identifying in vivo DNA binding sites of transcription factors and for studying chromatin modifications. Unfortunately,...
Luis G. Acevedo, A. Leonardo Iniguez, Heather L. Holster, Xinmin Zhang, Roland Green, Peggy J. Farnham
A review of current NIH funding (performed by NIH Sales *
* Data provided by NIH Sales, Inc., 2 Snowmound Ct., Rockville, MD 20850, USA. Phone: 301-279-7175. www.nihsales.net
for...
Steven Q. Irvine
To facilitate the handling of small invertebrate embryos during whole-mount in situ hybridization, a method of solution exchange using laboratory mini-columns was developed. This protocol speeds...
Kevin Ahern
You don't have to travel 20,000 leagues under the sea to view over 30,000 species of fish. All you need to do is trawl the waters of FishBase to reel in the big ones, which at this time includes over...
Manfred Kayser
Bi-parentally inherited short tandem repeat polymorphisms have been routinely used in human identity testing for about 25 years. More recently, the analysis of uni-parentally inherited markers from...
Nijsje Dorman
Most of us enjoy special effects in a movie theater, but it's no fun if our eyes fool our brain when it comes to research. Unfortunately, Jaiswal et al . report that an accepted method of visualizing...
George P. Anderson, Russell Matney, Jinny L. Liu, Andrew Hayhurst, Ellen R. Goldman
Phage display is a well-known technique that facilitates the selection of peptides or proteins that bind to a desired target. Using this tool, binding elements contained in the natural immune...
Jonathan Minden
The goal of comparative proteomics is to analyze proteome changes in response to development, disease, or environment. This is a two-step process in which proteins within cellular extracts are first...
Sumiko Ohashi-Kunihiro, Masafumi Yohda, Haruhiko Masaki, Masayuki Machida
We have developed a novel vector, pTCS, as a tool for efficient selection of open reading frame (ORF)-containing inserts. In pTCS clones containing an insert with an ORF, a downstream marker gene...
