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Peyton Cook, Chunxiao Fu, Morgen Hickey, Eun-Soo Han, Kenton S. Miller
Relative real-time reverse transcription PCR (RT-PCR) has become an important tool for quantifying changes in messenger RNA (mRNA) populations following differential development or stimulation of...
Scott J. Tebbutt, Jian-Qing He, Kelly M. Burkett, Jian Ruan, Igor V. Opushnyev, Ben W. Tripp, Jeffrey A. Zeznik, Chiaka O. Abara, Colleen C. Nelson, Keith R. Walley
We have developed a robust microarray genotyping chip that will help advance studies in genetic epidemiology. In population-based genetic association studies of complex disease, there could be hidden...
Manjula Reddy
A number of selection systems have been developed for direct selection of recombinant plasmids in cloning experiments (positive selection). In this study, the commonly used LacZ-based...
Ledare Habera, Naomi Smith, Ryan Donahoo, Kurt Lamour
1 , 2 ), mapping ( 3 ), and gene discovery ( 4 ). Genomic DNA or cDNA is digested with restriction enzymes in the presence of synthetic adaptors in a “restriction/ligation” reaction...
Partha M. Das, Kavitha Ramachandran, Jane vanWert, Rakesh Singal
Association between proteins and DNA is crucial for many vital cellular functions such as gene transcription, DNA replication and recombination, repair, segregation, chromosomal stability, cell cycle...
Daniel F. Lusche, Hanni Rötzer, Rudolf Merz, Hubert Fink, Rupert Mutzel, Christina Schlatterer
Suspensions of Dictyostelium discoideum amoebae display free-running light scattering oscillations at the onset of development. We describe a device to monitor these oscillations in several samples...
John C. March, William E. Bentley
1 2 3 4 5 ). Also referred to as posttranscriptional gene silencing, RNAi is exquisitely specific for the targeted gene and encompasses sense, antisense, or double-stranded RNA (dsRNA) molecules,...
Lynne Lederman
How can our accumulated knowledge of nucleic acids, proteins, and other molecules be translated into an understanding of how the cells, tissues, organs, and ultimately organisms that contain them...
Claire L. Simpson, Valerie K. Hansen, Pak C. Sham, Andrew Collins, John F. Powell, Ammar Al-Chalabi
High-throughput genotyping technologies such as DNA pooling and DNA microarrays mean that whole-genome screens are now practical for complex disease gene discovery using association studies. Because...
John E. Ladbury
1 2 3 4 5 ) uses the extremely accurate measurement of heat as a probe for an interaction as it occurs. Knowing the concentrations of the interacting moieties allows the calculation of the observed...
Jinxiu Shi, Qiang Liu, Vu Q. Nguyen, Steve S. Sommer
Robust dosage PCR (RD-PCR), a duplex and quantitative PCR, detects large heterozygous deletions and duplications in genomic DNA samples. RD-PCR amplifies an endogenous internal control and a target...
