Fluxion Biosciences introduces the IonFlux-HT and IonFlux-16 Automated Patch Clamp Systems. These new systems combine Fluxion's proprietary microfluidic technology with integrated electronics to automate the traditional patch clamp assay. Ideal applications include primary/secondary screening, lead optimization, and toxicology screening. The IonFlux-HT system includes 64 amplifiers and delivers 8000–10,000 assays per day at a cost of just 30 cents per data point using 384-well plates, reports the company. The IonFlux-16 provides all the features of the HT system with 16 amplifiers, utilizing a 96-well plate format. Both the IonFlux-HT and IonFlux-16 systems utilize standard well-plate formats with integrated microfluidic channels for cell patching and compound addition, according to the company. The systems employ a familiar plate reader format for simplicity and integration with existing automated liquid handlers. The IonFlux technology automates cell manipulation, trapping, sealing, whole-cell formation and precise voltage protocols. Voltage clamping occurs continuously during all fluidic operations. Automated compound addition during the voltage protocol provides delivery to the cells in 50 ms, making the system ideal for ligand-gated channels.
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Fluxion Biosciences provides cellular analysis tools for use in critical life
science research and drug discovery applications. Fluxion’s proprietary
microfluidic platform enables precise functional analysis of individual
cells in a multiplexed format. Fluxion’s systems meet the rigorous demands
of life science and drug discovery scientists by providing an intuitive,
easy-to-use operating system for single-cell biology.