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Antibody-Based Technologies
Octave Chromatography System
Dorton Analytical's Octave System is able to continuously process chemical or biological samples, including racemates, cell lysates, cell culture supernatants, and other crude fractions to yield grams of highly purified antibodies, proteins, sugars, amino acids, fatty acids, and other large and small molecules in just hours.
The Octave is a compact, versatile and affordable system based upon Simulated Moving Bed Chromatography (SMBC), a multicolumn continuous method that has been well-established for industrial scale production of sugars, pharmaceuticals, and petrochemicals. The counter-current flow created by SMBC enables extremely efficient utilisation of stationary and mobile phases and operation at high feed concentrations, leading to dramatic increases in productivity versus conventional batch methods. The same benefits SMBC is proven to bring to industrial chromatography are delivered to the laboratory benchtop with the innovative Octave System. The Octave System is able to continuously process chemical or biological samples, including racemates, cell lysates, cell culture supernatants, and other crude fractions to yield grams of highly purified antibodies, proteins, sugars, amino acids, fatty acids, and other large and small molecules in just hours. The Octave chromatography platform is a powerful enabling technology for drug discovery, nutraceutical, food, renewable fuel and fine chemical research and development. The Octave System carries eight column positions arranged in series and connected through a proprietary pneumatic valve array. The programmable 72-valve array contains no moving parts, occupies only 3 ?l per valve, and responds within 100 ms. Fluid flow is controlled by four independent pumps. The valve and pump configuration provides ultimate flexibility in programming chromatographic protocols via the intuitive software. All flow paths consist of metal free biocompatible materials that are also compatible with common organic solvents and clean-in-place solutions. With its small footprint, the Octave Chromatography System carries more purification capability than any other similar size chromatography instrument. The Octave System is available in two configurations with maximum flow rates up to 10 and 100 ml/min.