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Antibody-Based Technologies
Octave Chromatography System
The Octave is a compact, versatile and affordable system based upon Simulated
Moving Bed Chromatography (SMBC), a multicolumn continuous method that has
been well-established for industrial scale production of sugars,
pharmaceuticals, and petrochemicals. The counter-current flow created by
SMBC enables extremely efficient utilisation of stationary and mobile phases
and operation at high feed concentrations, leading to dramatic increases in
productivity versus conventional batch methods. The same benefits SMBC is
proven to bring to industrial chromatography are delivered to the laboratory
benchtop with the innovative Octave System. The Octave System is able to
continuously process chemical or biological samples, including racemates,
cell lysates, cell culture supernatants, and other crude fractions to yield
grams of highly purified antibodies, proteins, sugars, amino acids, fatty
acids, and other large and small molecules in just hours. The Octave
chromatography platform is a powerful enabling technology for drug
discovery, nutraceutical, food, renewable fuel and fine chemical research
and development.
The Octave System carries eight column positions arranged in series and
connected through a proprietary pneumatic valve array. The programmable
72-valve array contains no moving parts, occupies only 3 ?l per valve, and
responds within 100 ms. Fluid flow is controlled by four independent pumps.
The valve and pump configuration provides ultimate flexibility in
programming chromatographic protocols via the intuitive software. All flow
paths consist of metal free biocompatible materials that are also compatible
with common organic solvents and clean-in-place solutions. With its small
footprint, the Octave Chromatography System carries more purification
capability than any other similar size chromatography instrument. The Octave
System is available in two configurations with maximum flow rates up to 10
and 100 ml/min.
