Sigma's CompoZr oncology disease model cell lines are designed to enable basic research and high-content, high-throughput screening of compounds and biologics.
These cell lines are designed to assist the development of personalized
medicine through target validation, identification of mechanistic actions of
drugs, and investigation of disease development, progression, and remission.
The cell lines should enable researchers to study the effect of the mutation
in its natural genomic context, using isogenic parental cells to help
evaluate specific modifications without complications arising from
background mutations. These human knockout and knock-in oncology cell lines
were created using the company’s CompoZr zinc finger nuclease (ZFN)
Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing.