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Cell Biology
Oncology disease model cell lines
Sigma's CompoZr oncology disease model cell lines are designed to enable basic research and high-content, high-throughput screening of compounds and biologics.
These cell lines are designed to assist the development of personalized medicine through target validation, identification of mechanistic actions of drugs, and investigation of disease development, progression, and remission. The cell lines should enable researchers to study the effect of the mutation in its natural genomic context, using isogenic parental cells to help evaluate specific modifications without complications arising from background mutations. These human knockout and knock-in oncology cell lines were created using the company’s CompoZr zinc finger nuclease (ZFN) technology.
 
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Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing.