Shimadzu Scientific Instruments PTM Finder software uses data mining to
investigate post-translational modifications in complex protein samples,
including data for hypothetical, novel modifications. The software is
designed for use with Shimadzu’s AXIMA line of MALDI mass spectrometers.
With PTM Finder software, users can identify peptide sequences carrying one or
more modifications using MS/MS data. The software performs consecutive
Mascot searches using all the functionality of MS/MS Ion Search.
If peptides do not match any proteins during a search, the user is directed
towards a module where they can define their own hypothetical modifications
and screen the remaining MS/MS data for specific shifts in fragment masses,
neutral losses and/or diagnostic ions. The queries are performed on a
reduced database of protein sequences to reduce search time. Users can also
import amino acid sequences with a copy/paste function or use the proteins
derived from the initial Mascot search results.
Shimadzu Scientific Instruments is the American subsidiary of Shimadzu Corp.,
headquartered in Kyoto, Japan. Founded in 1875, Shimadzu is a $2 billion
multinational corporation with three major divisions: Medical Diagnostics,
Aerospace/Industrial and Analytical Instruments. The Analytical Division is
one of the world’s largest manufacturers of analytical instrumentation and
environmental monitoring equipment. In 1975, SSI corporate headquarters was
established in Columbia, Md., to provide analytical solutions to
laboratories in North, Central and parts of South America. In the United
States, SSI has a network of more than 50 locations providing local and
regional sales, service and technical support.