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Genomics
Pre-designed CompoZr Knockout zinc finger nucleases
Sigma Life Science's pre-designed CompoZr Knockout zinc finger nucleases (ZFNs) are designed to knockout any gene in the human genome.
Priced to fit within the budget of a typical laboratory, these ZFNs can generate permanent and heritable gene knockouts in human cell lines within weeks. Sigma has designed CompoZr ZFNs that will produce a knockout in each gene by inducing a double-strand break at a defined site within the gene’s first three exons. This double strand break stimulates the cell's natural DNA repair pathways, resulting in a permanent, site-specific deletion or mutation that disrupts the gene’s function. Robust and on-target gene knockout using CompoZr Knockout ZFNs is guaranteed by functional validation prior to shipment and unique enhancements to the DNA-recognition and cleavage ZFN subunits. More sophisticated genetic modifications, such as single nucleotide substitutions, can be generated through Sigma Life Science’s CompoZr Custom ZFN Service.
 
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Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing.