Sigma Life Science's pre-designed CompoZr Knockout zinc finger nucleases (ZFNs) are designed to knockout any gene in the human genome.
Priced to fit within the budget of a typical laboratory, these ZFNs can
generate permanent and heritable gene knockouts in human cell lines within
Sigma has designed CompoZr ZFNs that will produce a knockout in each gene by
inducing a double-strand break at a defined site within the gene’s first
three exons. This double strand break stimulates the cell's natural DNA
repair pathways, resulting in a permanent, site-specific deletion or
mutation that disrupts the gene’s function. Robust and on-target gene
knockout using CompoZr Knockout ZFNs is guaranteed by functional validation
prior to shipment and unique enhancements to the DNA-recognition and
cleavage ZFN subunits.
More sophisticated genetic modifications, such as single nucleotide
substitutions, can be generated through Sigma Life Science’s CompoZr Custom
Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing.