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High-Throughput Screening, Mass Spectrometry, Molecular Biology
RapidFire 300 assay analysis system
BioTrove’s RapidFire 300 system performs rapid screening of in vitro ADME assays. The system uses a high-throughput, mass spectrometry-based method to analyze the assays in six to eight seconds per sample, and is significantly faster than systems that use conventional HPLC mass spectrometry techniques. The RapidFire 300 allows researchers to perform a wide range of in vitro ADME assays with 24-hour, unattended operation. It is fully compatible with any manufacturer's triple quadruple mass spectrometer and provides data that can be used with existing laboratory information management systems. The RapidFire 300 system can be used for a variety of in vitro ADME applications, including CYP inhibition, metabolic stability, p-glycoprotein inhibition, plasma protein binding, permeability assays, and CYP induction.
 
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BioTrove, Inc. offers two innovative technology platforms: OpenArray®, which advances genomic research in a wide range of life science fields, including agriculture, disease research, and public health, and RapidFire®, which enables the acceleration of drug discovery and pipeline decisions. With 11 of the top 12 largest biopharmaceutical companies based on global sales as clients, and partnerships with prestigious research and public health centers around the world, BioTrove's products and services ensure that an industry committed to accuracy and speed can meet business goals.

The OpenArray® Platform enables genomics researchers to generate SNP and real time qPCR data in the hundreds of thousands of data points per day, significantly increasing the number of samples analyzed while significantly decreasing the time and cost required. The flexible format and nanoliter scale of the OpenArray system allows for easy adjustment of sample and assay numbers, achieving economical, high-throughput genomics. Life Technologies globally markets the OpenArray SNP genotyping platform under the TaqMan® OpenArray® SNP Genotyping brand. BioTrove is a licensee of Life Technologies global patent rights related to the real-time thermal cyclers, microfluidics and data analysis.

RapidFire® Mass Spectrometry (RF-MS) feeds samples directly to the mass spectrometer at six to eight seconds per sample, eliminating the bottleneck created by traditional mass spectrometry throughput.  RF-MS is routinely used in many applications including the high-throughput screening of previously intractable drug targets, ADME assays and directed evolution studies.