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Phenotypic High Content Screening and Label-free Approaches to Accelerate Drug Discovery

Phenotypic High Content Screening and Label-free Approaches to Accelerate Drug Discovery Webinar

Available Now On Demand:
www.biotechniques.com/Phenotypic


Cell-based multivariate phenotypic assays can accelerate both target-centric and phenotypic drug discovery as their rich content provides information on desired effects and possible modes of action. Growing evidence indicates that results generated from phenotypic assays are especially effective in discovering first-in-class drugs. This is why many scientists are using phenotypic approaches alongside traditional target-based methods to make new findings and to ensure the physiological relevance of their results early in the process.

This webinar features:

* Presentations on two different approaches to phenotypic screening, from running the screen to identifying hits.

* A discussion on the use of high content imaging in phenotypic screening for drug discovery research.

* The latest research on the application of cell-based label-free phenotypic assays for analyzing G-protein-coupled receptor (GPCR) responses.

* A live Q&A session

Moderator:

Patrick C.H. Lo, Ph.D.
Senior Editor, BioTechniques

Speakers:

David L. Roman, Ph.D.
Associate Professor of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences & Experimental Therapeutics, The University of Iowa College of Pharmacy

Val J. Watts, Ph.D.
Professor of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University

Christopher Hale, Ph.D.
Scientist, Discovery Technologies, Amgen Inc.

Sponsored by:

PerkinElmer

Available Now On Demand:
www.biotechniques.com/Phenotypic


Video Date: November 03 2014 Run Time:

Using CRISPR/Cas9 to Understand Transcription and Control Gene Expression
Web Event

Available Now On Demand:

www.biotechniques.com/CRISPR

CRISPR/Cas9 presents a new way for researchers to explore how gene expression is controlled and regulated in cells. Although we know much about this process, recent discoveries (new RNAs, alternative splicing events) make it clear that there is much more to be learned about how genomes encode biological information.

This webinar features:

• The latest advances in CRISPR/Cas9 technology and how these advances are being applied in clever and creative ways to explore genome function

• A discussion of best practices for CRISPR/Cas9 targeting and design

• A live question and answer session

Speakers:

Timothy K Lu - Dept. of Biological Engineering, MIT

Evan Whitehead - Dept. of Cellular and Molecular Pharmacology, UCSF Center for Systems and Synthetic Biology

Moderator:

Patrick C.H. Lo, Ph.D. - Senior Editor, BioTechniques

Sponsored by:

Available Now On Demand:

www.biotechniques.com/CRISPR

Confocal and Two-photon Microscopy Methods for Imaging the Brain

Confocal and Two-photon Microscopy Methods for Imaging the Brain


A FREE Web Event



Available Now On Demand

A deeper understanding of brain function requires visualization of the complex architecture of neurons and their connections. With the ability to peer deeper into samples than conventional light microscopy approaches, confocal and two-photon microscopy are proving to be indispensable tools for such brain mapping studies. In this special webinar, two researchers working at the cutting-edge of brain imaging will discuss their applications of the latest confocal and two-photon microscopy techniques. From fluorescent labeling and imaging of neural circuits using the Brainbow system to in vivo imaging of brain structure, function, and blood flow, this webinar will give researchers a deeper appreciation of the potential for new microscopy methods to unlock the secrets of the cellular world. Unique insights into sample handling and processing of multicolor images will also be presented, and attendees will have the opportunity to ask questions.

Moderator:

Patrick C.H. Lo, Ph.D.
Senior Editor, BioTechniques

Speakers:

Dawen Cai, Ph.D.
Assistant Research Scientist, Department of Physics,
University of Michigan

Ian R. Winship, Ph.D.
Assistant Professor, Neurochemical Research Unit,
Department of Psychiatry,
University of Alberta

Sponsored by:

A Free Web Event

www.biotechniques.com/microscopy


Exploring Neurons and Synapses: Imaging Tools and Techniques
Online Event

Available Now On Demand:
www.biotechniques.com/synapses

In the coming years, considerable effort and resources will be directed at understanding the neural connections of the brain.

This webinar examines many of the tools being used to study how neurons interact with one another at their synapses.

This event will provide both experienced and novice researchers with an excellent overview of the current optical imaging methods driving neuroscience today.


This webinar features:

• An introduction to STED super-resolution imaging technology

• The application of STED imaging and other techniques for studying the overall organization of the synaptic bouton and for analyzing synaptic vesicle recycling and the localization of synaptic proteins

• A description of how STED microscopy has helped to refine our understanding of the morphological and functional dynamics of synapses in living specimens

• A live question and answer session

Speakers:

Silvio Rizzoli - Department of Neuro- and Sensory Physiology, European Neuroscience Institute, University of Göttingen Medical Center

Valentin Nagerl - Interdisciplinary Institute for Neuroscience (IINS), University of Bordeaux

Moderator:

Patrick C.H. Lo, Ph.D. - Senior Editor, BioTechniques

Sponsored by:

Available Now On Demand:
www.biotechniques.com/synapses

Workshop on Recent Advances and Applications of Laser Capture Microdissection
Virtual Event

Workshop on Recent Advances and Applications of Laser Capture Microdissection

A Free Web Event
Available on Demand Now

Since its introduction in 1996, laser capture microdissection (LCM) has emerged as an important technique for isolation of specific subsets of cells from complex tissues or other biological samples. Cellular material isolated by LCM is often used in downstream applications including PCR, microarray analysis, and sequencing. Several recent advances in LCM approaches have enhanced and expanded the range of these applications even further. In this web-based workshop, an overview of LCM will be provided along with descriptions and discussions of several recent LCM technology advances.

Attendees will:

  • Learn about the development and evolution of LCM approaches, including common applications and troubleshooting tips
  • Gain valuable insights into new developments in LCM technology, including the development of expression microdissection techniques
  • Engage in a discussion/question and answer session with a panel of LCM experts

Moderator:

Patrick C.H. Lo, Ph.D.
Associate Editor, BioTechniques

Speakers:

Robert Bonner, Ph.D.
Head, Section of Medical Biophysics. National Institute of Child Health and Human Development, National Institutes of Health

Michael Tangrea, Ph.D.
Staff Scientist, Pathogenetics Unit. National Cancer Institute, National Institutes of Health

Jason Hipp, MD., Ph.D.
Rabson fellow, Laboratory of Pathology, National Cancer Institute, National Institutes of Health

Sponsored by:

A Free Web Event
Available on Demand Now