Aberrant DNA methylation patterns have been implicated in many disease systems, including cancer. Bisulfite sequencing is the gold standard in assessing the methylation status of a particular region because only sequencing provides direct detection of methylation events, as well as information across the entire amplified region.
Vendor-submitted protocol.
Published in
December 2006
2007
DNA methylation patterns—are often considered as a second code, an additional layer of information superimposed on the DNA code that determines many phenotypic attributes.