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CRISPRon or CRISPRoff?

Written by Francesca Lake (Editor-in-Chief)

CRISPRoff CRISPRon DNA editing

In the latest CRISPR news, scientists have been able to modify CRISPR’s basic architecture to extend its editorial reach to the epigenome, developing a new tool called ‘CRISPRoff’. On the other side of the pond, a team has built a new tool to detect unintended, on-target mutations. CRISPRoff allows scientists to switch off the majority of human genes, without editing the genetic code. The team, from the University of California San Francisco (UCSF; CA, USA) and the Whitehead Institute (MA, USA), demonstrated that once the gene is off, it remains inert in the cell’s descendants for as many as 450...

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