eBook | Advances in autoimmune disease therapeutics
Autoimmune diseases are a group of disorders that cause the immune system to mistakenly attack healthy cells, tissues or organs. Central to the process are cytokines, which exhibit dual functionality in autoimmune diseases as regulators of immune homeostasis and as drivers of disease. Therapeutic approaches that target cytokines, such as monoclonal antibodies and biologic therapies, have been developed and have since become established approaches for treating autoimmune diseases. More recently, emerging research on HLA-DR+ T regulatory cells, a distinct class of Tregs with unique biological properties, and CAR-T cells has shown their potential as therapeutic strategies for autoimmune diseases.
In this eBook, we explore both established and emerging therapeutic approaches, offering insights into new areas of research and innovative strategies for autoimmune disease drug development.
- Introduction
- In Focus summary: Autoimmune disease research solutions
- Infographic: Autoimmune diseases: the era of targeted treatments
- Application note: Cytokine networks in autoimmune diseases: mechanisms, pathogenesis and therapeutic innovations
- Application note: Precision targeting of autoimmune disease
- Review: Innovative strategies for the discovery of new drugs against alopecia areata: taking aim at the immune system
- Review: Immunomodulatory role and therapeutic potential of HLA-DR regulatory T cells in systemic lupus erythematosus
- Review: Autoimmune neuro-ophthalmic disorders: pathophysiologic mechanisms and targeted biologic therapies
