A guide to accelerating cell-line development for commercial production

Biopharmaceutical drug products are quickly becoming an essential branch of the healthcare industry. Primarily consisting of therapeutic recombinant proteins, biopharmaceuticals have had considerable success in treating various diseases, particularly cancers and inflammatory disorders. However, developing a reliable process for commercial biopharmaceutical production is logistically and technically demanding, with many opportunities for projects to break down. Biopharmaceutical manufacturing uses living host cells as production centers. The development of a robust, high-yielding cell line is the foundation of a reliable production process. However, cells introduce a source of variability and a unique set of technical challenges. Early awareness of the possible obstacles...