Single-cell spatial proteomics

Single-cell and spatial techniques have evolved in leaps and bounds over the last decade, spreading from genomics into each omic realm. The latest developments for spatial techniques in the proteomics sphere overcome previous limitations concerning resolution and multiplex capabilities, to deliver spatial proteomics at a single-cell resolution for multiple proteins.

This In Focus, supported by Pixelgen Technologies (Stockholm, Sweden), explores how such techniques have granted researchers access to information regarding the cell-surface proteome, providing examples of their applications across the life sciences.