Urea-based amino sugar agent clears murine liver and preserves protein fluorescence and lipophilic dyes
Method Summary
This study presents a simplified protocol for optically clearing murine liver tissue in only 24 h using one simple urea-based amino sugar solution and a single incubation. This method preserves fluorescence of transgenically expressed proteins and lipophilic tracer dyes within the context of native spatial morphology.
Authors: Hough M, Fenlon M, Glazier A et al.