Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis
A significant fraction of sudden death in children and young adults is due to viral myocarditis, an inflammatory disease of the heart. Here we used single-cell and spatial transcriptomics to establish the cellular targets of the virus and the molecular events that lead to reovirus-induced myocarditis in neonatal murine hearts. Our data give insights into the cell-type specificity of innate immune responses, and into the transcriptional states of inflamed cardiac cells that recruit circulating immune cells, including cytotoxic T cells, which induce pyroptosis. Overall, we observe a complex network of cellular phenotypes and cell–cell interactions associated with viral myocarditis.
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What will you learn?
- Viral myocarditis
- Cardiovascular disease
- Viral pathogenesis
- Spatial transcriptomics
- Single-cell transcriptomics
Speaker
Madhav Mantri
PhD Candidate
Prof. Iwijn DeVlaminck’s Lab, Cornell University (NY, USA)
I am Madhav Mantri, a Computational Biology PhD candidate in Iwijn De Vlaminck’s lab at Cornell University (NY, USA). Broadly, I want to understand dynamic cellular processes during development and immune-related disease through the lens of gene regulation. Currently, I am using high-throughput single-cell and spatial transcriptomics to map and understand cardiac development and inflammation.
This webinar was recorded on Thursday 28th April 2022
In association with
