Bringing scale and single-cell resolution to functional CRISPR screens

CRISPR screening is a powerful method to investigate how the quantitative expression of certain genes affects complex cellular phenotypes and processes. With Chromium Single-Cell CRISPR Screening from 10x Genomics, researchers can profile hundreds of different CRISPR perturbations and detect single-guide RNAs (sgRNAs) with directly linked gene expression phenotypes at single-cell resolution. This comprehensive approach empowers researchers to explore the complete transcriptomic effects of genetic perturbations with greater throughput, experimental efficiency, and resolution than bulk CRISPR screening or individual knockouts.