CRISPR toolbox grows

Written by Caitlin Killen

New CRISPR platform RESCUE introduces new potential therapeutic targets with novel RNA edits. In recent years CRISPR has dominated the field, transforming our ability to target disease-linked genetic mutations. Previously, enzymes Cas9 and Cas12 have been used to enact change in DNA, with Cas13 targeting RNA. Whilst these methods have proved effective there has been a need for more specific tools to be developed. Some cell types, such as neurons, are resistant to editing with CRISPR. In other cases, the ability to bring about short term effects is an attractive prospect. The CRISPR toolbox has expanded again. Alongside his team,...

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