Advanced flow cytometry applications for antibody, small molecule and phenotypic screening

Multiplexed, multiparameter screening assays are foundational to the drug discovery process. By collecting more information, more rapidly – whether the focus antibodies, small molecules, or phenotypic screening – researchers have more confidence in therapeutic candidates as they progress through the discovery and development process.

Flow cytometry is a powerful analytical tool with many applications including antibody and small molecule screening and cell phenotyping. It can be quite complex, however, for researchers to integrate into their workflows, limiting direct access to the technology and necessitating the use of centralized core labs, which can slow the pace of discovery.

This review summarizes recent peer-reviewed publications describing use of the iQue® Advanced Flow Cytometry Platform for antibody, phenotypic and small molecule screening, as well as novel applications such as extracellular vesicles and siRNA delivery system screening.