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Mechanism of Zika neurological complications revealed

Written by Storm Johnson (Commissioning Editor)

Zika virus

Brazilian research groups collaborate to uncover a correlation between high levels of Gas6 protein and the neurological complications of Zika virus infection.

The study was a collaboration between Brazilian researchers from several groups whose leaders include José Luiz Proença, Fábio Trindade Maranhão Costa (both University of Campinas’s Institute of Biology; São Paulo, Brazil) and Jean Pierre Schatzmann Peron (University of São Paulo’s Biomedical Sciences Institute; Brazil). Singapore’s A*STAR Infectious Diseases Labs also collaborated in the study. Modena’s group used ELISA immunoassays to analyze the levels of Gas6 protein in Zika patient blood serum samples whilst Peron’s group conducted animal trials. The findings demonstrated that higher levels of Gas6 protein correlated with neurological complications after Zika virus infection.

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