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Tech Blast | Organ-on-a-chip models of fatty liver disease

Cell and tissue biology Diagnostics and preclinical Drug discovery and development

In this Tech Blast episode, we discuss preclinical models of non-alcoholic fatty liver disease with Gareth Guenigault, Lead Scientist of Services at CN Bio (Cambridge, UK). Gareth provides an overview of the non-alcoholic steatohepatitis (NASH) therapeutic landscape and explains how incorporating organ-on-a-chip models into drug discovery workflows can improve this landscape.

Get Gareth’s expert insight into the field and discover how to develop liver-on-a-chip NASH models, tips for analyzing the resultant data, and the future of organ-on-a-chip technologies.

Contents:

  • Introduction: 00:00–00:30
  • Pathology and prevalence of NASH: 00:30–01:50
  • Challenges faced when developing drugs for NASH: 01:50–03:40
  • An overview of organ-on-a-chip models: 03:40–05:05
  • Liver-on-a-chip models for NASH: 05:05–07:05
  • Incorporating organ-on-a-chip into drug discovery workflows: 07:05–08:45
  • Accessing liver-on-a-chip and NASH models: 08:45–09:45
  • The NASH-in-a-box workflow: 09:45–10:45
  • Gareth’s tips for analyzing the data: 10:45–12:15
  • The future of organ-on-a-chip technology: 12:15–13:55

This content was supported by CN Bio.