Introducing cancer genomics with long reads
Short-read sequencing technologies have enabled numerous discoveries in cancer genomics over the last 20 years, but the limit of their exploratory value is fast approaching. New technologies with long-read sequencing capabilities are enabling researchers to re-examine cancer genomics in higher resolution, with the ability to parse information from the regions of the genome previously inaccessible to short-read techniques, such as structural variants and differentially methylated regions.
This webinar details the Schatz lab’s efforts to maximize the potential of these long-read sequencing capabilities by integrating them into sophisticated methods for the analysis of cancer genomes.
What will you learn?
- How to increase read count and enable accurate copy number detection in cancer genomes using short molecule nanopore sequencing
- A fast and accurate method for SV refinement, comparison, and population analysis, using Jasmine (https://github.com/mkirsche/Jasmine)
- How to use UNCALLED and UNCALLED4 (https://skovaka.github.io/UNCALLED/) for nanopore signal analysis
- Discuss the role of telomere-to-telomere (T2T) genomes now and in the future of cancer genomics
Speaker
Michael Schatz
Bloomberg Distinguished Professor of Computer Science and Biology
Johns Hopkins University
Schatz’s research opperates at the intersection of computer science, biology, and biotechnology, and focuses on the development of novel algorithms and systems for comparative genomics, human genetics, and personalized medicine. You can find more information about his work on his lab website: http://schatz-lab.org
This webinar was recorded on Tuesday 27 March 2023.
In association with
