A new technique for super-resolution imaging improves upon an existing system using DNA labels. Researchers from the University of Exeter, in collaboration with the University of Cambridge and Imperial College London (all UK), have built upon the existing DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) technique to create the better performing Repeat DNA-PAINT. This technique decreases background noise and improves accuracy, while maintaining spatial resolution. Both DNA-PAINT and Repeat DNA-PAINT work by attaching markers to molecules of interest in a cell. The single DNA strand markers are then labelled with complementary DNA which can be labelled by a florescent...
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